Coverage of GWAS

| category Bioinformatics  | tag NGS 

naive estimate of coverage of all SNPs in the genome (G)

\[ \frac{T+L}{R} \]

R: a reference set of SNPs T: tag SNPs L: SNPs are in LD with a SNP in T

corrected genomewide coverage

\[ \frac{\frac{L}{R-T}(G-T)+T}{G} \]

G: the number of common SNPs in the genome.


  • Jeffrey C Barrett & Lon R Cardon. Evaluating coverage of genome-wide association studies. NATURE GENETICS, VOLUME 38, NUMBER 6, PAGE 656-662, JUNE 2006.

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